R. Le
2011
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Journal
Chemical Reagents
Abstract
Glycine and L-glutamine were used as main raw materials for synthesizing glycyl-L-glutamine.At first phthalic anhydride was used to perform amino protection to glycine.Then the product reacted upon sulfurous oxychloride to yield phthalylglycyl chloride,followed by amination reaction with L-glutamine.Finally,the as-synthesized product yielded the glycyl-L-glutamine through deprotection by hydrazine hydrate in methanol solution.The crude product can meet the requirement for the pharmaceutical grade purity through primary purification.