G. Grotenbreg, Martijn Kronemeijer, Mattie S. M. Timmer
Oct 16, 2004
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0
Influential Citations
37
Citations
Journal
The Journal of organic chemistry
Abstract
A practical gram-scale and high-yielding synthesis of the antimicrobial peptide gramicidin S is presented. An Fmoc-based solid-phase peptide synthesis protocol is employed for the generation of the linear decapeptide precursor, which is cyclized in solution to afford the target compound. The versatility of our method is demonstrated by the construction of eight gramicidin S analogues (15a-h) having nonproteinogenic sugar amino acid residues (4-7) incorporated in the turn regions.