Zeng-jun Guo
2006
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Journal
Chemical Industry and Engineering
Abstract
Isochroman was synthesized from phenyl ethanol by inner molecular Friedel-Crafts alkylation reaction.The intermidiate of Ropinirole 4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one was prepared from isochroman by ring opening,salt formation,hydrolysis,nitrostyrene formation and Royer reaction.The target product was confirmed by the analysis of TLC,()~(1)H-NMR,IR.The total yield is 31.51%.