W. Ha
2013
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Journal
Guangzhou Chemical Industry
Abstract
N-Protected(S)-ethyl-2-amino-3-(diethylphosphono) propanoate was the key intermediate for preparing L-2-amino-3-phosphonopropionic acid.An enantioselective synthetic approach was developed for N protected(S)-ethyl-2-amino-3-(diethylphosphono) propanoate.It was synthesized from N-protected L-serine by two steps,Mitsunobu reaction and nuleophilic addition,and the structure confirmed by1H NMR and13C NMR.