H. Bi
2015
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Journal
Journal of Jinan University
Abstract
5-bromo-2-(( 4-chlorobenzyl) oxy) bromomethyl benzene( III) was synthesized from 1-chloro-4-( chloromethyl) benzene and 5-bromo-2-hydroxybenzaldehyde by eliminationreaction,reduction reaction and bromization. N-( piperidine-4-yl)-N-propylbenzamide( IV) was prepared from 1-benzylpiperidine-4-one. Further reaction of III with IV gave a novelnon-peptide CCR5 antagonist Benzamide derivatives. The structure of these products was characterized by 1HNMR,13 CNMR and MS,and The products were tested for biological activity.