O. I. Dyubchenko, V. Nikulina, A. F. Markov
May 1, 2006
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Pharmaceutical Chemistry Journal
Abstract
A series of 2(4)-hydroxybenzyl-and 3-(4-hydroxyaryl)propylamines and their hydrochlorides were synthesized based on 2,4-and 2,6-alkylsubstituted phenols. The synthesized hydrophilic derivatives are characterized by average half-lethal doses (LD50), which fall within 50–170 mg/kg for intraperitoneal administration in mice. Some of the synthesized compounds in a dose of 0.1LD50 show pronounced hepatoprotector activity with respect to tetrachloromethane-induced model toxic hepatitis in mice.