Liang Fu-b
2014
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
A novel compound,N-(4,6-Dimethylpyrimidin-2-yl)-N'-[3-(4-trifluoromethylphenyl)-5-methyl-isoxazol-4-yl]acyl thiourea(5),was synthesized by a four-step reaction from ethyl 3-(4-trifluoromethylphenyl)-5-methyl-4-isoxazole carboxylic acid ester and 2-amino-4,6-dimethylpyrimidine.The structure was characterized by1 H NMR,IR,ESI-MS,elemental analysis and X-ray single-crystal diffraction.5 belongs to triclinic system,space group P-1 with a = 7.351(6) ,b = 10.373(10),c = 14.120(12) ,α = 72.222(14) °,β = 85.372(15) °,γ = 85.380(14) °,V = 1 020.1(16)3,Z =2,Dc =1.418 g·cm-3,μ =0.211 mm-1,F(000) =448,R1= 0.088 2,wR2= 0.229 7.In the crystal,the thiourea moiety and pyrimindine ring are almost coplanar,and two intermolecular hydrogen bonds strengthen the integration of the 2D network.Preliminary biological activities test indicated that 5(at 100 mg·L-1) exhibited good inhibitory activity against D.ciliaris and B.napu,inhibition rate were 82.8% and 84.3%,respectively.