Zhou Li-shan
2012
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Journal
Journal of Tianjin University
Abstract
Trimethyl-phenylethynyl-silane or trimethyl-thiophen-2-ylethynyl-silane was mediated by Negishi reagent to form 2,5-bis(trimethylsilyl)zirconacyclopentadienes,which reacted with dimethyl acetylenecarboxylates(DMAD) in the presence of copper chloride to obtain benzene derivatives in high selectivity with good yields.Methyl and trimethylsilyl(TMS)substituted zirconacyclopentadienes reacted with 3-phenyl-propynoic acid dimethylamide and 3(4-methoxy-phenyl)-1-phenyl-propynone in the presence of NiBr2(PPh3)2 respectively to obtain unsymmetrical benzene derivatives.This reaction led to the highly selective one-pot formation of benzene derivatives by intermolecular coupling of different internal unsymmetrical alkynes.