V. Aggarwal, Franck J Sandrinelli, J. Charmant
Feb 13, 2002
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract trans-(2S,5S)-(1,1-Diphenylmethyl)pyrrolidine has been prepared from the corresponding diester in four steps and 54% overall yield. Key steps involve the nucleophilic addition of an organomagnesiun reagent to a carbonyl compound promoted by cerium(III) chloride and the reductive removal of benzylic trimethylsilyloxyl groups with Me3SiCl–NaI–MeCN and water.