S. Vidyacharan, A. Sagar, D. Sharada
Jul 8, 2015
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0
Influential Citations
21
Citations
Journal
Organic & biomolecular chemistry
Abstract
We have demonstrated for the first time the use of 2H-indazole as a diene partner in an aza hetero-Diels-Alder reaction leading to highly substituted 4-aminoquinolines via a heterocylic-heterocylic (H-H) strategy and have further developed a tandem one-pot method starting from 2-azidobenzaldehyde by the formation of 2C-N, 1N-N and 1C-C bonds. The key features of the present protocol are readily available starting materials, mild reaction conditions, being work-up free and having easy purification. This is the first time where the synthesis of 4-aminoquinoline drug like molecules has been achieved starting from simple starting materials in an atom economical manner.