John A. Hill, J. Eaddy
Aug 1, 1994
Citations
0
Influential Citations
3
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
2-Methyl-2-[[(7-methyl-7H-benzo[c]carbazol-10-yl)methyl]amino]-1,3-propanediol (1, 7U85) was synthesized as the mesylate salt in the [14C]-labelled form with specific activity 48.4 mCi/mmol suitable for metabolism and tissue distribution studies in animals The synthetic sequence involved the regiospecific synthesis of a bromobenzo[c]carbazole by a modified Fischer indole synthesis, formylation by a Bouveault reaction, and reductive amination. The radiochemical purity was > 97.3%.