Xiaofei Chen, Fangjun Xiong, Wen‐xue Chen
Mar 6, 2014
Citations
0
Influential Citations
33
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient asymmetric synthesis of atorvastatin calcium has been achieved from commercially available diethyl 3-hydroxyglutarate through a novel approach that involves an organocatalytic enantioselective cyclic anhydride desymmetrization to establish C(3) stereogenicity and cyanide-free assembly of C7 amino type side chain via C5+C2 strategy as the key transformations.