Valentina Hrast, Alenka Mrcina, D. Kikelj
Jan 15, 1999
Citations
0
Influential Citations
13
Citations
Journal
Chemical Physics Letters
Abstract
Abstract ( R )-Monomethyl 2-methyl-2-(2-nitrophenoxy)malonates obtained by PLE catalyzed hydrolysis of the corresponding dimethyl malonates undergo solvent-dependent enantioselective cyclization to afford ( R )-methyl 2-methyl-3-oxo-3,4-dihydro-2 H -1,4-benzoxazine-2-carboxylates and ( S )-2-methyl-3-oxo-3,4-dihydro-2 H -1,4-benzoxazine-2-carboxylic acids, respectively. These compounds are easily converted to enantiomerically and diastereomerically pure carboxamides, which are used as peptidomimetic building blocks.