H. Abe, Saki Sato, Wakana Oishi
Aug 1, 2019
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Journal
Tetrahedron Letters
Abstract
Abstract The first total synthesis of tricyclic humulanolide wilfolide B was achieved. The synthetic strategy involved: i) radical cyclization with samarium(II) iodide to construct the bicyclic lactone from an acyclic compound, and ii) ring-closing metathesis to build the eight-membered ring by connecting two side chains, thus completing the tricyclic framework.