M. Gao, Yan Yang, Yan‐Dong Wu
Aug 26, 2010
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Influential Citations
95
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Quality indicators
Journal
Organic letters
Abstract
A highly efficient synthesis of hydantoins has been developed from simple and commercially available 1,3-dicarbonyl compounds, ureas, and methyl ketones or terminal aryl alkenes. This protocol involves a sustainable integration of two coupled domino processes: iodine-promoted synthesis of unsymmetrical 1,4-enediones (domino I) and the sequential transformation into hydantoins (domino II).