Liu Yuan-yua
2014
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Journal
Fine chemicals
Abstract
Propranolol hydrochloride was synthesized from α-naphthol,epoxy chloropropane and isopropylamine via a series of reactions including etherification,elimination,ammoniation and salt formation. Then,its two derivatives,O-acetyl propranolol hydrochloride( compound Ⅳ) and polyacrylic acid immobilized propranolol hydrochloride( compound Ⅶ),were prepared by the reaction of propranolol hydrochloride with acetyl chloride and polypropylene chloride,respectively. Their structures were characterized by means of melting point,IR,1HNMR,and single-crystal X-ray diffraction analysis. The hydrolysis results under acidic conditions indicate that the releasing rate of propranolol hydrochloride in compounds Ⅳ and Ⅶ within 8 h was 15. 18% and 17. 86%,respectively. Compared with that of compound Ⅳ,the polymeric carrier of compound Ⅶ is not easy to be absorbed by the body and can be expected to be used as prodrug for clinical application.