En Da
2012
Citations
0
Influential Citations
1
Citations
Journal
Fine chemicals
Abstract
3,4-Dihydroxyphenylacetic acid was directly given from the starting material 3,4-dimethoxyphenylacetic acid.Methyl 3,4-dihydroxyphenylacetate was obtained from the reaction of 3,4-dihydroxyphenylacetic acid with SOCl2 in methanol.It is the first time that the important natural product hydroxytyrosol was obtained by using sodium/ethanol reduction on the basis of Bouveault-Blanc classic reaction,thus providing a novel synthetic method of hydroxytyrosol.The resulting product was characterized by means of 1HNMR,IR and MS.In addition,the influence of the molar ratio of methyl 3,4-dihydroxyphenylacetate to sodium,reaction time and reaction temperature on the yield of hydroxytyrosol was investigated.The mechanism for the reductive reaction of methyl 3,4-dihydroxyphenylacetate with sodium/reduction was discussed.