Z. Szűcs, M. Sathekge, B. Marjanovic-Painter
2011
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Influential Citations
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary investigation into the potential of 4-iodophenylacetic acid radiolabelled by 131I as a radiopharmaceutical equivalent. The radiolabelling by isotope exchange gave a radiochemical yield of 53±6%, and a radiochemical purity of 97.8±1.2% as qualified by HPLC. The product contained 4% ester by-product and is suitable for studies in animals. Copyright © 2010 John Wiley & Sons, Ltd.