Ian P Leader, J. Halket, P. Finch
Jul 30, 2004
Citations
1
Influential Citations
5
Citations
Journal
Rapid communications in mass spectrometry : RCM
Abstract
Two potential oxidation degradants of oxymetazoline have been isolated by liquid chromatography and monitored by electrospray single quadrupole mass spectrometry. The structures of the products are shown to be oxymetazoline N-oxide and hydroxyamine by multiple-stage fragmentation ion trap mass spectrometry. The product ion spectra were installed in a library database and the library was used to examine an aged commercial product; one of the degradants was detected, but at a level of less than 0.1% of the parent.