Zhang Wei-jie, W. Ping
2011
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Journal
Modern Chemical Industry
Abstract
N-benzyloxycarbonyl-L-asparagine underwent cyclization,esterification,methylation,De-Cbz reaction to afford the key intermediate(4S)-1-methyl-2-oxo-imidazolin-4-carboxylic acid tert-butyl,followed by acylation with N-[(S)-1-ethyoxyoxo-3-phenylpropyl]-L-alanine and removal of tertbutyl group using hydrochloride gas to generate imidapril hydrochloride.The total yield is about 26%(based on N-Carbobenzyloxy-L-asparagine).