S. Mavel, J. Renou, C. Galtier
Apr 1, 2001
Citations
0
Influential Citations
12
Citations
Journal
Arzneimittelforschung
Abstract
Summary The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.