D. Chu, A. Claiborne
Jan 8, 1991
Citations
0
Influential Citations
13
Citations
Journal
ChemInform
Abstract
The synthesis of 6-fluoro-7-piperazin-1-yl-9-cyclopropyl-2,3,4,9-tetrahydroisothiazolo[5,4-b][1,8]naphthyridine-3,4-dione and 6,8-difluoro-7-piperazin-1-yl-9-cyclopropyl-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione are described. The key step includes the one-pot formation of 2-phenylthio derivatives of 1,4-dihydro-4-oxo[1,8]naphthyridine-3-carboxylic acid ester and its corresponding quinoline derivative by condensation of a β-ketoester with phenyl iminochlorothioformate. A simple and practical synthesis of iminochlorothioformates utilizing isothiocyanates and mercaptans in also described