F. Khaliullin, E. K. Alekhin, E. E. Klen
2004
Citations
0
Influential Citations
3
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
In continuation of the search for immunotropic compounds among 1-(thietan-3-yl)benzimidazole derivatives [1], we have synthesized a series of new salts and hydrazides of (benzimidazolyl-2-thio)acetic acids containing thietane cycles. Reactions of 2-[1-(thietan-3-yl)(Ia) and 2-[1-(1,1-dioxothietan-3-yl)(Ib) benzimidazolyl-2-thio]acetic acids with bases (amino alcohols or sodium hydroxide) led to the corresponding salts IIa – IIh. Using ethyl esters IIIa and IIIb, obtained by reacting acids Ia and Ib with ethanol in the presence of sulfuric acid, we synthesized (benzimidazolyl-2-thio)acetic acid hydrazides IVa and IVb, respectively. For biological tests, hydrazides IVa and IVb were converted into dihydrochlorides Va and Vb, respectively.