W. Nawrocka, M. Zimecki
Jul 1, 1998
Citations
0
Influential Citations
20
Citations
Quality indicators
Journal
Archiv der Pharmazie
Abstract
2‐Aminobenzimidazole reacted with selected esters of α,β‐unsaturated acids and α,β‐unsaturated ketones to form derivatives of 1,2,3,4‐tetrahydropyrimido[1,2‐a]benzimidazol‐2‐ones, 1,4‐dihydropyrimido[1,2‐a]benzimidazoles, and 2‐acetylaminobenzimidazole. 2‐Cinnamoylaminobenzimidazole, 4‐phenyl‐1,2,3,4‐tetrahydropyrimido[1,2‐a]benzimidazol‐2‐one, 4‐(benzimidazol‐2‐yl‐amino)‐4‐phenylbutan‐2‐one, and 4‐methyl‐2‐phenyl‐1,2,3,4‐tetrahydropyrimido[1,2‐a]benzimidazole were tested for their potential activity in immunological assays in the mouse model. Compound 1, at a dose of 100 μg/mouse, significantly inhibited the humoral immune response and, at the same time, stimulated the cellular type of that response. The proliferative response of mouse splenocytes to concanavalin A was inhibited only at a higher dose (2 μg/ml). The immunotropic activity of 4, on the other hand, was uniformly strongly inhibitory in all applied tests. The suppressive activity of 4 was lower in the cellular immune response and proliferation tests than that of cyclosporin A.