Liu Chunxin
2009
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Journal
Journal of Sichuan University of Science & Engineering
Abstract
Study on the synthesis of 1-(4-Methylphenyl) ethylnicotinate is of positive significance for realizing its domestical production.In this experiment,4-methyl acetophenone was reduced to 1-(4-Methylphenyl) ethanol,and nicotinoyl chloride was prepared by nicotinic acid,then 1-(4-Methylphenyl)ethylnicotinate was synthesized from 1-(4-Methylphenyl) ethanol and nicotinoyl chloride.Though orthogonal experiment,synthesis technology had been optimized.The yield reaches 70%,the purity of product is above 98%.