W. Xiao
2003
Citations
0
Influential Citations
2
Citations
Journal
Chinese Journal of Applied Chemistry
Abstract
The reaction of diketene and cinnamyl alcohol gave cinnamyl acetoacetate. Cinnamyl acetoacetate was ammoniatzed to give cinnamyl 3-aminocrotonate. Methyl acetoacetate condensed with 3-nitrobenzaldehyde to form methyl 2-(3-nitrobenzylidene)acetoacetate which then via. Hantzsch cyclization with cinnamyl 3-aminocrotonate produced new calcicum antagonist pranidipine under mild conditions. The total yield was 69% based on cinnamyl alcohol. Pranidipine synthesized has been characterized by IR? 1H NMR? 13C NMR and MS spectral measurements.