Ji Guang-hui
2008
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To synthesis 3-(3-hydroxy-1-methylpropoxy)1-butanol(Ⅰ) and 3-(3-hydroxybutoxy)-1-butanol(Ⅲ),and to improve its synthetic procedure.Methods The target compounds were synthesized from 1,3-butandiol through 4-step reactions including catalytic condensation by sulfuric acid,selective protection by triphenylchloromethane,separation,and deprotection.Results and conclusion The structure of compound Ⅰ was confirmed by 1H-NMR,13C-NMR,and its purity determined by GC was higher than 99.5%,purity of compound Ⅲ was 90.0%.