Xu Xing-you
2003
Citations
0
Influential Citations
0
Citations
Journal
Journal of Huaihai Institute of Technology
Abstract
Tropisetron hydrochloride was synthesized from indol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol in an overall yield of 50% (the yield of literature was only 20%). Oxalyl chloride is replaced by thionyl chloride in chloride acetylation. The process was simple, the reaction conditions were mild, and the product was easily purified and suitable for scale-up production.