W. Biao, Cao Sheng, Du Yue
2016
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Journal
Fine Chemical Intermediates
Abstract
To perform the quality control of dapagliflozin, two impurities of dapagliflozin including 5-bromo-2-chlorophenyl-2′-ethoxyldiphenylmethanone(1) and 5-bromo-2-chloro-2′-ethoxyl diphenylmethane(2) were synthesized. Impurity 1 was prepared via condensation, Fries rearrangement and ethylation using 5-bromo-2-chlorobenzoic acid and phenol as the starting materials. Impurity 2 was obtained from reduction of impurity 1.The structures of Impurity 1 and Impurity 2 were characterized using1 H NMR and MS.