A. Korolev, A. Shchekotikhin, L. Lysenkova
Mar 1, 2003
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Journal
Synthesis
Abstract
Two methods for the synthesis of (indol-3-yl)methanesulfonamide were elaborated based on the switching off the reactivity of the indole nucleus in the intermediates by using indoline or indoxyl compounds. (2,3-Dihydroindol-3-yl)methanesulfonic acid was the key compound used in the indole-indoline approach and (1-acetyl-3-hydroxy-2,3-dihydroindol-3-yl)-N-(tert-butyl)methanesulfonamide was the key intermediate when 1-acetylindoxyl was used as the starting compound.