Shen Xin-an
2008
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Journal
Modern Chemical Industry
Abstract
In an industrial scale,indole-3-carboxaldehyde is obtained in a yield of 87.1% from indole by Vilsmeier-Haack reaction with phosphorus oxychloride and N,N-dimethylfomamide.Under the temperature between 50-60℃ indole-3-carboxaldehyde is reduced with potassium borohydride to give indole-3-carbinol in the presence of methylbenzene and water.The yield of indole-3-carbinol can reach 69.0%.