Archana., V. K. Srinivastava, Ashok Kumar
2003
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0
Influential Citations
17
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Journal
Indian Journal of Pharmaceutical Sciences
Abstract
A series of 2-(substituted arylidenyl imino)-5-(3' indolomethylene)-I,3,4-thiadiazoles have been synthesized via condensation of 2-amino-5-(3'-indolomethylene)-I,3,4-thladlazole(3) with various aromatic alde-hydes. Cycloaddition of thioglycolic acid to 4-8 yielded 3-[5-(3"indolo-methylene)-I',3',4'-thiadiazol-2'-yl]-2-substitutedaryl-4-thiazolidinones and with diazonlum salt solution of 4-8 gave I-[5'-(3"-indolomethylene]-2'-imino-I',3',4'-thiadiazol-2'-yl]-I,3-disubstitutedaryl)-formazans. These compounds were screened for anticonvulsant activity and acute toxicity. Compound 3-(3'-indolomethylene-1',3',4'-thiadiazol-2'-yl)-2-(p-methoxy-phenyl)-4-thiazolidinones showed most potent anticonvulsant activity. The structure of all the synthesized compounds were delineated by element analysis, IR and proton magnetic resonance.