Ching-Yao Chang, Teng‐Kuei Yang
Aug 1, 2003
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2 S , 3′ S )-2-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1 H -benzo[ b ]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4 , has been achieved through an asymmetric reduction of 4-(2-nitrophenyl)-2,4-dioxobutyric acid ethyl ester 6b employing baker's yeast as the reductive catalyst.