D. -. Kim, Yeon Ju Kim
Dec 1, 1993
Citations
0
Influential Citations
8
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Both enantiomers of 2-benzyl-3-mercaptopropanoic acid were synthesized starting with racemic 3-acetylthio-2-benzylpropanoic acid methyl ester using a kinetic resolution with α-chymotrypsin as a key step, and their inhibitory activities against carboxypeptidase A were determined to show that the S-isomer is much more potent (Ki = 7.8 × 10−9 M) than the racemic acid (Ki = 1.1 × 10−8 M).