Lili Ding, Ju Zhu, Canhui Zheng
Nov 15, 2011
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of new substituted 4-amino-N-(diaminomethylene) benzenesulfonamides were synthesized and their in vitro acrosin inhibitory activities were evaluated. Most of the compounds showed potent acrosin inhibitory activities with compounds 4o and 4p being significantly more potent than the control compound N-alpha-tosyl-L-lysyl-chloromethyl-ketone (TLCK). The compounds provide a new scaffold for the development of acrosin inhibitory agents.