T. Li, Ling Zhang, Zhe-Shan Quan
Feb 1, 2009
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0
Influential Citations
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Citations
Quality indicators
Journal
Chinese Chemical Letters
Abstract
Abstract In an attempt to search for more potent positive inotropic agents, a series of 1-(benzylamino)-3-(4,5-dihydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy)propan-2-ol derivatives was synthesized in four steps using 6-hydroxy-3,4-dihydro-2(1 H )-quinolinone as a starting material, and their positive inotropic activities were evaluated by measuring the coronary blood flow (CBF) and the left ventricular pressure (LVP) followed by calculating the rate of pressure development (dp/dt max values) in the preparation of rat Langendorff's heart. Three compounds ( 5d , 5g , 5j ) showed favorable activities, among which 5g was shown the most potent with dp/dt max value of 9.7% and CBF value of 17.8% at a concentration of 1 × 10 −5 mol/L in our in vitro study.