Liu Qian-chun
2010
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Journal
Fine Chemical Intermediates
Abstract
2-(2-Amino-4-thiazolyl)-2-[[(Z)-(t-butoxycarbonyl)methoxy]imino]-acetic acid 2-benzothiazolyl thioester (1),an intermediate for cefixime,was synthesized from methyl acetoacetate via 2-(2-amino-4-thiazolyl)-2-(Z)-hydroxy imino methyl acetate (4) in 17.9% overall yield.4 was prepared in one-pot synthesis.