Li Yuan-xiang
2008
Citations
0
Influential Citations
0
Citations
Journal
Fine Chemical Intermediates
Abstract
Methyl 2,6-dihydroxybenzoate was first synthesized with 2,6-dihydroxybenzoic acid as the raw materials through reaction of absolute methanol in the presence of the strong sulfuric acid or BF3·Et2O,the yield was 43.5% and 46% respectively. Then methyl 2,6-bis(4,6-dimethoxy-pyrimidin-2-yloxy)benzoate was synthesized from methyl 2,6-dihydroxy-benzoate and 4,6-dimethoxy-2-(methylsulfonyl)pyrimidine(DMSP) in the presence of K2CO3 in acetone,and the yield was 91.5%. The previous intermediate can be formed 2,6-bis(4,6-dimeth-oxypyrimidin-2-yloxy)benzoic acid via hydrolyzation with the 20% KOH and acidification with the 0.7 % citric acid,and the yield was 72%.