Bai Zheng-wu
2008
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Journal
Journal of Wuhan Institute of Technology
Abstract
The synthesis of two intermediates of iobitridol has been studied.2-Isopropyl-5-carboxy-1,3-dioxane was prepared using diethyl malonate as starting material with a total yield of 47.5%,through a series of reactions of hydroxymethylation,dihydroxy-protection,saponification,acidification,decarboxylation.In addition,an attempt to prepare 2,2dimethyl-5-carboxy-1,3-dioxane was also made.1H NMR spectrum showed that 2,2-dimethyl-5,5-dicarboxy-1,3-dioxane hydrolyzed in differently acidy solution.The final product was confirmed by elemental analysis and 1H NMR.