G. Sundararajan, R. Govindharaju, D. Rajaraman
2021
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Journal
Rasayan Journal of Chemistry
Abstract
A series of novel 2,4,6-trichlorophenylhydrazines of 3,3-dimethyl-2,6-diphenyl-4-(-2-(2,4,6trichlorophenyl)hydrazono)piperidines were synthesized and characterized by IR, Mass, 1H NMR, 13C NMR, 1H–1H COSY and 1H–13C COSY spectra. Newly synthesized compound Antimicrobial study revealed that compounds (6-9) exhibited excellent in vitro antibacterial activity against S. aureus and B. subtilis antifungal activity against C. albicans, C. tropicalis, A. niger and A. flavus. Molecular docking studies indicated that the synthesized compounds 6-9 possessed appreciable binding energy values against PDB ID: 3LD6 protein. It was more attractive to speculate that the result of the antimicrobial activities varied with the nature of the substituent on the 2,4,6-trichlorophenyl hydrazine at the C-4 position.