Yu Kun
2008
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Journal
Journal of Shandong University of Technology
Abstract
The synthesis process of irsogladine maleate was studied based on the Japaness process but without the synthesis of 2,5-2 chlorine benzonitrile.2,4-Diamino-6-(2,5-dichlorophenly)-1,3,5-triazinemaleate were synthesized and then Irsogladine Maleate was sythesized using I-Pr Potassium instead of hydrogen oxidized potassium in wreath in order to lift alkalescence.Through 70 batches of experiments,liquid chromatography was used to analyze its content.The Irsogladine content is 99.5%,Irsogladine Maleate content is 98.5%.These two contents even exceed the standards of Japanese pharmacopoeia.