Jeonghan Park, Jeffrey C. Moore, Feng Xu
Jan 15, 2016
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0
Influential Citations
3
Citations
Journal
Organic Process Research & Development
Abstract
A practical through-process to prepare iso-Boc (S)-2-amino-8-nonenoic acid has been developed. The short synthesis utilizes a highly enantioselective, enzymatic reductive amination of an α-keto acid substrate, which is prepared via a Grignard addition to diethyl oxalate. Starting from 7-bromohept-1-ene and without isolation of any intermediates, iso-Boc (S)-2-amino-8-nonenoic acid is prepared in 60% overall yield and >99.9% ee.