V. Subramanian, V. Batchu, Deepak K. Barange
May 17, 2005
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Journal
The Journal of organic chemistry
Abstract
The coupling reaction of o-iodobenzoic acid with terminal alkynes by using a catalyst system of 10% Pd/C-Et3N-CuI-PPh3 has been studied in a variety of solvents. 3-Substituted isocoumarins were formed in good yields and with good regioselectivity when the reaction was performed in EtOH.