Zhong Wei-hui
2010
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Zhejiang Chemical Industry
Abstract
The methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno [2,3-c]-pyridin-6(7H)-yl)acetate,an isomer of clopidogrel,was achieved from 2-chlorophenylglycine methyl ester and 2-(3-thiophenyl)ethyl para-toluenesulfonate via amino substitution,Mannich reaction and formation of sulfate salt in 56%.The advantages of our method are commercially available starting materials,mild reaction condition and high yield.