A. Shamroukh, M. Zaki, Eman M. H. Morsy
Jul 1, 2007
Citations
0
Influential Citations
63
Citations
Journal
Archiv der Pharmazie
Abstract
6‐Amino‐5‐imino‐pyrazolo[4′,3′:5,6]pyrano[2,3‐d]pyrimidine derivative 4 and pyrazolo‐[4′,3′:5,6]pyrano[2,3‐d]pyrimidin‐5‐ylhydrazine derivative 5 were prepared starting from 6‐amino‐3‐methyl‐4‐(p‐nitrophenyl)‐2,4‐dihydropyrano[2,3‐c]pyrazole‐5‐carbonitrile 1. The synthesis and structure characterization of 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐e][1,2,4]triazolo[4,3‐c]pyrimidine derivatives 7 and 9 and their isomerization to 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐e] [1,2,4]triazolo[1,5‐c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions are reported. Moreover, the synthesis of 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐e] tetrazolo[1,5‐c]pyrimidine derivative 14 and N9‐acyclic nucleoside 15 are described. Some of the prepared products showed potent antimicrobial activity.