Thirupathi Reddy Yerramreddy, A. Yiannikouris
Aug 13, 2021
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Letters in Organic Chemistry
Abstract
An improved and alternative method for the total synthesis of isophytol from citral via using pseudoionone intermediate was developed and described in this manuscript. This alternative commercially viable approach involved six steps and represents an alternative commercially viable over existing published synthetic methods in the literature. This goal was achieved by developing and optimizing an efficient and high yield procedure for the synthesis of a key intermediate i.e., 6,10,14 trimethylpentadectrimethylpentadec-5-en-2-one by reacting 2-methoxypropene with a tertiary alcohol (3,7,11 trimethyldodec-1-ene-3-ol). Isophytol was provided in 58-60% overall yield from citral with >99% purity, evaluated by TLC, GC, and NMR.