D. Taber, R. Herr, D. Gleave
Jan 10, 1997
Citations
0
Influential Citations
36
Citations
Journal
The Journal of organic chemistry
Abstract
A total synthesis of the isoprostane (+/-)-8-epi-PGF(2)(alpha) ethyl ester (5) is described, based on the diastereoselective cyclization of alpha-diazo ketone 7. This ketone is assembled by aldol condensation between alpha-diazo ketone 8 and aldehyde 9. The sequential alpha-diazo ketone aldol/insertion described here offers a powerful new approach to cycloalkane construction.