C. Peixoto, P. Laurin, M. Klich
Mar 11, 2000
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory potency in negative supercoiling of relaxed DNA gyrase.