R. Mohareb, H. F. Zohdi, S. Sherif
1994
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron
Abstract
Abstract The reaction of phenyl isothiocyanate with the Knovenagel condensated active methylene compounds 1a-d gave the non-isolable salts 3a-d . The latter underwent in-situ heterocyclization on treatment with some halogenated compounds e.g. phenacyl bromide, ethyl bromoacetate δ-bromoacetoacetanilide, ethyl δ-bromoacetoacetate and δ-bromo-β-oxo-butyronitrile into the corresponding polyfunctionally substituted 3-(thiazol-2′-yliene)pyridine derivatives, which could also be annulated into fused heterocyclic ring systems. Chemical and spectroscopic evidences for the structure of the new compounds are described.