S. M. Ivanov
Feb 1, 2021
Citations
0
Influential Citations
0
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
3-tert-Butyl-8-nitro-7-R-pyrazolo[5,1-c][1,2,4]triazin-4(6H)-ones (R = H, Cl, Br, NO2, N3) were prepared by nitration with HNO3/H2SO4 of the corresponding 7-R-substituted 8-carboxylic acids or their analogs with a vacant C8 position. The latter were synthesized by diazotization of 7-amino-3-tert-butyl-4-oxo-4,6-dihydropyrazolo[5,1-c][1,2,4]triazin-8-carboxylic acid. The electrophilic halogenation and cycloaddition of the 7-azido and 7-nitro derivatives of the synthesized compounds were considered. The structures of the products were confirmed by IR, heteronuclear NMR spectroscopy, HRMS, and single-crystal XRD.